Standard of care PsA

Overview

Striving for and achieving high treatment targets is linked to substantial benefits for your SpA patients in terms of:

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Quality of life

Achieving MDA in PsA is associated with significant improvements in 6 of the 8 SF-36 domains, including physical functioning, pain and general health1

Structural progression

Patients who achieve sustained MDA show significant reductions in radiographic progression compared to patients who never achieve MDA²

Patient function

Changes in DAPSA are significantly correlated with a change in the HAQ-DI and patients in DAPSA remission show a constant decline in HAQ-DI scores, thus improved functionality, during 6 years of follow-up³

Quality of life

Achieving MDA improves patient quality of life¹

Achieving MDA in PsA is associated with significant improvements in 6 of the 8 SF-36 domains, including physical functioning, pain and general health.

Change from baseline in SF-36 domain scores at Week 24 by MDA responder status
PsA/Quality of Life
Change from baseline in SF-36 domain scores at Week 24 by MDA responder status
Patient function

Greater disease control is associated with improved functionality³

Changes in DAPSA are significantly correlated with a change in the HAQ-DI and patients in DAPSA remission show a constant decline in HAQ-DI scores, thus improved functionality, during 6 years of follow-up.

Correlation between changes in PsA disease activity (ΔDAPSA) and changes in functional indices (ΔHAQ-DI) over 3 years of follow-up
PsA/Patient Function
graph

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If you have questions or want to know more, please reach out to our medical team.

References
1
Adapted from Coates LC et al. BMC Rheumatol. 2018;2:24.
2
Adapted from Kavanaugh A et al. Arthritis Care Res. 2016;68(2):267–274.
3
Adapted from Cruz LV et al. EULAR 2020. Abstract AB0843.
Acronyms
CASPAR
classification criteria for psoriatic arthritis
DAPSA
disease activity index for psoriatic arthritis
HAQ-DI
health assessment questionnaire-disability index
MDA
minimal disease activity
PsA
psoriatic arthritis
SF-36
36-Item Short Form Survey
SHS
Sharp/van der Heijde Score
SpA
spondyloarthritis